Bioprocess engineering principles / Pauline M. Doran
- Bib ID:
- 5978174
- Format:
- Book
- Author:
- Doran, Pauline M
- Edition:
- 2nd ed.
- Description:
-
- Waltham, MA : Academic Press, ©2013
- viii, 919 p. : ill. ; 24 cm.
- ISBN:
-
- 9780122208515
- 012220851X
- Full contents:
-
- Machine generated contents note: 1.Bioprocess Development: An Interdisciplinary Challenge
- 1.1.Steps in Bioprocess Development: A Typical New Product from Recombinant DNA
- 1.2.A Quantitative Approach
- 2.Introduction to Engineering Calculations
- 2.1.Physical Variables, Dimensions, and Units
- 2.2.Units
- 2.3.Force and Weight
- 2.4.Measurement Conventions
- 2.5.Standard Conditions and Ideal Gases
- 2.6.Physical and Chemical Property Data
- 2.7.Stoichiometry
- 2.8.Methods for Checking and Estimating Results
- Summary of Chapter 2
- References
- Suggestions for Further Reading
- 3.Presentation and Analysis of Data
- 3.1.Errors in Data and Calculations
- 3.2.Presentation of Experimental Data
- 3.3.Data Analysis
- 3.4.Graph Paper with Logarithmic Coordinates
- 3.5.General Procedures for Plotting Data
- 3.6.Process Flow Diagrams
- Summary of Chapter 3
- References
- Suggestions for Further Reading
- 4.Material Balances
- 4.1.Thermodynamic Preliminaries
- Contents note continued: 4.2.Law of Conservation of Mass
- 4.3.Procedure for Material Balance Calculations
- 4.4.Material Balance Worked Examples
- 4.5.Material Balances with Recycle, Bypass, and Purge Streams
- 4.6.Stoichiometry of Cell Growth and Product Formation
- Summary of Chapter 4
- References
- Suggestions for Further Reading
- 5.Energy Balances
- 5.1.Basic Energy Concepts
- 5.2.General Energy Balance Equations
- 5.3.Enthalpy Calculation Procedures
- 5.4.Enthalpy Change in Nonreactive Processes
- 5.5.Steam Tables
- 5.6.Procedure for Energy Balance Calculations without Reaction
- 5.7.Energy Balance Worked Examples without Reaction
- 5.8.Enthalpy Change Due to Reaction
- 5.9.Heat of Reaction for Processes with Biomass Production
- 5.10.Energy Balance Equation for Cell Culture
- 5.11.Cell Culture Energy Balance Worked Examples
- Summary of Chapter 5
- References
- Suggestions for Further Reading
- 6.Unsteady-State Material and Energy Balances
- Contents note continued: 6.1.Unsteady-State Material Balance Equations
- 6.2.Unsteady-State Energy Balance Equations
- 6.3.Solving Differential Equations
- 6.4.Solving Unsteady-State Mass Balances
- 6.5.Solving Unsteady-State Energy Balances
- Summary of Chapter 6
- References
- Suggestions for Further Reading
- 7.Fluid Flow
- 7.1.Classification of Fluids
- 7.2.Fluids in Motion
- 7.3.Viscosity
- 7.4.Momentum Transfer
- 7.5.Non-Newtonian Fluids
- 7.6.Viscosity Measurement
- 7.7.Rheological Properties of Fermentation Broths
- 7.8.Factors Affecting Broth Viscosity
- 7.9.Turbulence
- Summary of Chapter 7
- References
- Suggestions for Further Reading
- 8.Mixing
- 8.1.Functions of Mixing
- 8.2.Mixing Equipment
- 8.3.Flow Patterns in Stirred Tanks
- 8.4.Impellers
- 8.5.Stirrer Power Requirements
- 8.6.Power Input by Gassing
- 8.7.Impeller Pumping Capacity
- 8.8.Suspension of Solids
- 8.9.Mechanisms of Mixing
- 8.10.Assessing Mixing Effectiveness
- Contents note continued: 8.11.Scale-Up of Mixing Systems
- 8.12.Improving Mixing in Fermenters
- 8.13.Multiple Impellers
- 8.14.Retrofitting
- 8.15.Effect of Rheological Properties on Mixing
- 8.16.Role of Shear in Stirred Fermenters
- Summary of Chapter 8
- References
- Suggestions for Further Reading
- 9.Heat Transfer
- 9.1.Heat Transfer Equipment
- 9.2.Mechanisms of Heat Transfer
- 9.3.Conduction
- 9.4.Heat Transfer Between Fluids
- 9.5.Design Equations for Heat Transfer Systems
- 9.6.Application of the Design Equations
- 9.7.Hydrodynamic Considerations with Cooling Coils
- Summary of Chapter 9
- References
- Suggestions for Further Reading
- 10.Mass Transfer
- 10.1.Molecular Diffusion
- 10.2.Role of Diffusion in Bioprocessing
- 10.3.Film Theory
- 10.4.Convective Mass Transfer
- 10.5.Oxygen Uptake in Cell Cultures
- 10.6.Factors Affecting Oxygen Transfer in Fermenters
- 10.7.Measuring Dissolved Oxygen Concentration
- Contents note continued: 10.8.Estimating Oxygen Solubility
- 10.9.Mass Transfer Correlations for Oxygen Transfer
- 10.10.Measurement of kLa
- 10.11.Measurement of the Specific Oxygen Uptake Rate, qO
- 10.12.Practical Aspects of Oxygen Transfer in Large Fermenters
- 10.13.Alternative Methods for Oxygenation without Sparging
- 10.14.Oxygen Transfer in Shake Flasks
- Summary of Chapter 10
- References
- Suggestions for Further Reading
- 11.Unit Operations
- 11.1.Overview of Downstream Processing
- 11.2.Overview of Cell Removal Operations
- 11.3.Filtration
- 11.4.Centrifugation
- 11.5.Cell Disruption
- 11.6.The Ideal Stage Concept
- 11.7.Aqueous Two-Phase Liquid Extraction
- 11.8.Precipitation
- 11.9.Adsorption
- 11.10.Membrane Filtration
- 11.11.Chromatography
- 11.12.Crystallisation
- 11.13.Drying
- Summary of Chapter 11
- References
- Suggestions for Further Reading
- 12.Homogeneous Reactions
- 12.1.Basic Reaction Theory
- Contents note continued: 12.2.Calculation of Reaction Rates from Experimental Data
- 12.3.General Reaction Kinetics for Biological Systems
- 12.4.Determining Enzyme Kinetic Constants from Batch Data
- 12.5.Regulation of Enzyme Activity
- 12.6.Kinetics of Enzyme Deactivation
- 12.7.Yields in Cell Culture
- 12.8.Cell Growth Kinetics
- 12.9.Growth Kinetics with Plasmid Instability
- 12.10.Production Kinetics in Cell Culture
- 12.11.Kinetics of Substrate Uptake in Cell Culture
- 12.12.Effect of Culture Conditions on Cell Kinetics
- 12.13.Determining Cell Kinetic Parameters from Batch Data
- 12.14.Effect of Maintenance on Yields
- 12.15.Kinetics of Cell Death
- 2.16.Metabolic Engineering
- Summary of Chapter 12
- References
- Suggestions for Further Reading
- 13.Heterogeneous Reactions
- 13.1.Heterogeneous Reactions in Bioprocessing
- 13.2.Concentration Gradients and Reaction Rates in Solid Catalysts
- 13.3.Internal Mass Transfer and Reaction
- Contents note continued: 13.4.The Thiele Modulus and Effectiveness Factor
- 13.5.External Mass Transfer
- 13.6.Liquid-Solid Mass Transfer Correlations
- 13.7.Experimental Aspects
- 13.8.Minimising Mass Transfer Effects
- 13.9.Evaluating True Kinetic Parameters
- 13.10.General Comments on Heterogeneous Reactions in Bioprocessing
- Summary of Chapter 13
- References
- Suggestions for Further Reading
- 14.Reactor Engineering
- 14.1.Bioreactor Engineering in Perspective
- 14.2.Bioreactor Configurations
- 14.3.Practical Considerations for Bioreactor Construction
- 14.4.Monitoring and Control of Bioreactors
- 14.5.Ideal Reactor Operation
- 14.6.Sterilisation
- 14.7.Sustainable Bioprocessing
- Summary of Chapter 14
- References
- Suggestions for Further Reading
- A.Conversion Factors
- B.Ideal Gas Content
- C.Physical and Chemical Property Data
- D.Steam Tables
- E.Mathematical Rules
- F.U.S. Sieve and Tyler Standard Screen Series.
- Notes:
- Includes bibliographical references and index.
- Subject:
- Copyright:
-
In Copyright
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Copyright status was determined using the following information:
- Material type:
- Literary Dramatic Musical
- Published status:
- Published
- Publication date:
- 1983
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